研发核心

刘艳华博士

Yanhua Liu, Ph.D.

个人简介

刘艳华,2012年获兰州大学化学专业学士学位,2017年获北京大学分析化学专业博士学位,研究方向为生物质谱。毕业后一直从事基于液质联用的生物分析工作,擅长小分子化合物的定量分析及蛋白质组学分析。

刘艳华

研究内容

致力于开发和验证B族维生素质谱定量检测新方法。

代表文章

1. Liu Y, Liu Q, Qi L, Ding T, Wang Z, Fu J, Hu M, Li M, Song J, Liu X. (2017) Temporal regulation of a Salmonella Typhimurium virulence factor by the transcriptional regulator YdcR. Mol. Cell. Proteomics, 16, 1683-1693.

2. Liu Y, Yu K, Zhou F, Ding T, Yang Y, Hu M, Liu X. (2017) Quantitative proteomics charts the landscape of Salmonella carbon metabolism within host epithelial cells. J. Proteome Res., 16, 788-797.

3. Liu Y, Zhang Q, Hu M, Yu K, Fu J, Zhou F, Liu X. (2015) Proteomic analyses of intracellular Salmonella enterica serovar Typhimurium reveal extensive bacterial adaptations to infected host epithelial cells. Infect. Immun., 83, 2897-2906.

4. Li Z, Liu Y, Fu J, Zhang B, Cheng S, Wu M, Wang Z, Jiang J, Chang C, Liu X. (2019) Salmonella proteomic profiling during infection distinguishes the intracellular environment of host cells. mSystems, 4, e00314-18.

5. Wang Z, Sun J, Tian M, Xu Z, Liu Y, Fu J, Yan A, Liu X. (2019) Proteomic analysis of FNR-regulated anaerobiosis in Salmonella Typhimurium. J. Am. Soc. Mass Spectrom., 30, 1001-1012.

6. Wang Z, McCloskey A, Cheng S, Wu M, Xue C, Fu J, Liu Y, Yu Z, Luo ZQ, Liu X. (2018) Regulation of the small GTPase Rab1 function by a bacterial glucosyltransferase. Cell Discov., 4, 53.

7. Wang Z, Sun J, Xia T, Liu Y, Fu J, Lo YK, Chang C, Yan A, Liu X. (2018) Proteomic delineation of the ArcA regulon in Salmonella Typhimurium during anaerobiosis. Mol. Cell. Proteomics, 17, 1937-1947.

8. Jiang J, Yu K, Qi L, Liu Y, Cheng S, Wu M, Wang Z, Fu J, Liu X. (2018) A proteomic view of Salmonella Typhimurium in response to phosphate limitation. Proteomes, 6, 19.

9. Xu J, Xu D, Wan M, Yin L, Wang X, Wu L, Liu Y, Liu X, Zhou Y, Zhu Y. (2017) Structural insights into the roles of the IcmS-IcmW complex in the type IVb secretion system of Legionella pneumophila. Proc. Natl. Acad. Sci. USA, 114, 13543-13548.

10.Zhou Y, Huang C, Yin L, Wang X, Wan M, Liu Y, Fu P, Zhang N, Liu X, Zhu Y. (2017) Nε-Fatty acylation of Rho GTPases by a MARTX toxin effector. Science, 358, 528-531.

11.Cheng S, Wang L, Liu Q, Qi L, Yu K, Wang Z, Wu M, Liu Y, Fu J, Hu M, Li M, Zhou D, Liu X. (2017) Identification of a novel Salmonella type III effector by quantitative secretome profiling. Mol. Cell. Proteomics, 16, 2219-2228.

12.Qi L, Hu M, Fu J, Liu Y, Wu M, Yu K, Liu X. (2017) Quantitative proteomic analysis of host epithelial cells infected by Salmonella enterica serovar Typhimurium. Proteomics, 17, 1700092.

13.Yu K, Wang Z, Zhou F, Jiang J, Liu Y, Hu M, Liu X. (2017) Quantitative analysis of Shigella flexneri protein expression under acid stress. Proteomics, 17, 1600381.

14.Fu J, Qi L, Hu M, Liu Y, Yu K, Liu Q, Liu X. (2017) Salmonella proteomics under oxidative stress reveals coordinated regulation of antioxidant defense with iron metabolism and bacterial virulence. J. Proteomics, 157, 52-58.

15.Hu C, Yu C, Liu Y, Hou X, Liu X, Hu Y, Jin C. (2015) A hybrid mechanism for the Synechocystis arsenate reductase revealed by structural snapshots during arsenate reduction. J. Biol. Chem., 290, 22262-22273.

16.He W, Huang T, Tang Y, Liu Y, Wu X, Chen S, Chan W, Wang Y, Deng Z, Liu X, Chen S, Wang L. (2015) Regulation of DNA phosphorothioate modification in Salmonella enterica by DndB. Sci. Rep., 5, 12368.

17.Lu Q, Yao Q, Xu Y, Li L, Li S, Liu Y, Gao W, Niu M, Sharon M, Ben-Nissan G, Zamyatina A, Liu X, Chen S, Shao F. (2014) An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis. Cell Host Microbe, 16, 351-363.

18.Hu M, Liu Y, Yu K, Liu X. (2014) Decreasing the amount of trypsin in in-gel digestion leads to diminished chemical noise and improved protein identifications. J. Proteomics, 109, 16-25.